Inhibition of microRNA-16 facilitates the paclitaxel resistance by targeting IKBKB via NF-kB signaling pathway in hepatocellular carcinoma_

Inhibition of microRNA-16 facilitates the paclitaxel resistance by targeting IKBKB via NF-kB signaling pathway in hepatocellular carcinoma

发布时间：2018-10-22

研究对象：microRNA-16；期刊：Biochemical and Biophysical Research Communications；影响因子：2.62；合作单位：中山大学附属第一医院器官移植中心；发表日期：2018年8月

摘要

Hepatocellular carcinoma (HCC) is a common malignant tumor usually resistant to chemotherapy.MicroRNAs play important roles in modulation of carcinogenesis and chemoresistance, which miR-16 hasbeen reported to mediate chemoresistance in many types of cancers. However, the role of miR-16 in HCC remains unknown. The aim of this study was to investigate whether miR-16 is participated in chemo resistance in HCC and shed light on the underlying molecular mechanisms. The fifindings of the current study discover that miR-16 is down-regulated in HCC tissue and cell lines. The results demonstrate that the inhibition of miR-16 renders resistance to paclitaxel in vitro and in vivo by targeting IKBKB via NF-kB signaling pathway, suggesting that miR-16 may be a meaningful therapeutic potential to overcome drug resistance in HCC.

Keywords: miR-16, IKBKB, Paclitaxel , resistance, NF-kB, Hepatocellular, carcinoma

合作部分结果

伯信合作技术

miRNA ISH探针

原文链接

https://doi.org/10.1016/j.bbrc.2018.06.113