实验原理：
MeRIP利用m6A特异性抗体识别并结合mRNA上的m6A甲基化修饰位点，以RNA免疫共沉淀方法富集甲基化修饰片段，同时，结合高通量测序与qPCR，在全转录组范围内研究发生m6A甲基化修饰的RNA区域，及其对基因表达的调控作用。
产品优势：
1. 快速省时
2. 稳定可靠
3. 配备完整
技术流程：
示例结果：
详见产品说明书：Bes5203-1 m6A MeRIP
详见产品说明书：Bes5203-2 m6A MeRIP（含m6A抗体）
文章案例
【2025年】
Article：M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.
Periodicals：Molecular Cancer
IF：33.900
Article：Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Periodicals：Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
IF：15.800
Article：Dynamic eIF3-S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts.
Periodicals：Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：ERβ/circAHNAK Axis Inhibits USP10-FMR1 Deubiquitination to Prevent m⁶A-Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma.
Periodicals：Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：Hsa_circ_0026782 Acts as a "Molecular Break" of CREB1-Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression.
Periodicals：Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
Periodicals：Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m6A/YTHDF1-mediated enhancement on ATG3 stability.
Periodicals：Theranostics
IF：12.400
Article：The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Periodicals：Theranostics
IF：12.400
Article：PARK7-driven IGF2BP3-K76 lactylation mediates ferroptosis and HAIC resistance in hepatocellular carcinoma.
Periodicals：Redox Biology
IF：11.900
Article：AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate cancer.
Periodicals：Journal of experimental & clinical cancer research: CR
IF：11.400
Article：ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer.
Periodicals：Cell Death & Disease
IF：9.600
Article：M6A-METTL3-dependent nuclear PANC754/PSPC1/H3K4me1 repression complex regulate immune evasive LGALS7 signal to enhance immunotherapy against colorectal cancer.
Periodicals：Cell Death & Disease
IF：9.600
Article：YTHDC1 phase separation drives the nuclear export of m6A-modified lncNONMMUT062668.2 through the transport complex SRSF3-ALYREF-XPO5 to aggravate pulmonary fibrosis.
Periodicals：Cell Death & Disease
IF：9.600
Article：XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1.
Periodicals：Cell Death & Disease
IF：9.600
Article： SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge.
Periodicals：Cellular & Molecular Biology Letters
IF：9.200
Article：METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Periodicals：Clinical and Translational Medicine
IF：7.900
Article：N6-Methyladenosine modification mediated by METTL3 promotes DNA-PKcs expression to induce anlotinib resistance in osteosarcoma.
Periodicals：Clinical and Translational Medicine
IF：7.900
Article： An exploration on the involvement of the methyltransferase like 3-m6A‑zinc finger MYM-type containing 1 axis in the progression of liver hepatocellular carcinoma.
Periodicals：International Journal of Biological Macromolecules
IF：7.700
Article：Pleckstrin-2 promotes the progression of colorectal cancer via YTHDF2-mediated TYMS mRNA stability.
Periodicals：Cellular and Molecular Life Sciences : CMLS
IF：6.200
Article：Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling.
Periodicals：Cell death discovery
IF：6.100
Article：MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.
Periodicals：International Journal of Molecular Medicine
IF：5.700
Article：Mettl3-Mediated N6-Methyladenosine Modification Mitigates Ganglion Cell Loss and Retinal Dysfunction in Retinal Ischemia-Reperfusion Injury by Inhibiting FoxO1-Mediated Autophagy.
Periodicals：Investigative Ophthalmology & Visual Scicence
IF：5.000
Article：SuoquanYishen formula improves renal cellular senescence by inhibiting YTHDF1-Rubicon axis to promote autophagy in diabetic kidney disease.
Periodicals：Frontiers in Pharmacology
IF：4.800
Article：GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification.
Periodicals：Molecular Neurobiology
IF：4.600
Article：Abnormal expression of CDC25C in NSCLC is influenced by transcriptional and RNA N6‑methyladenosine‑mediated post‑transcriptional regulation.
Periodicals：International Journal of Oncology
IF：4.500
Article：AQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway.
Periodicals：Journal of cellular and molecular medicine
IF：4.300
Article：Wilms' tumor 1-associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A-dependent manner.
Periodicals：Cell Biology International
IF：3.300
Article：METTL3-mediated m6A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis.
Periodicals：American Journal of Cancer Research
IF：2.900
【2024年】
Article：Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.
Periodicals：Molecular cancer
IF：27.700
Article：Natural product mediated mesenchymal-epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA.
Periodicals：Acta Pharmaceutica Sinica. B
IF：14.700
Article：circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models.
Periodicals：Nature communications
IF：14.700
Article：M6A-mediated upregulation of lncRNA TUG1 in liver cancer cells regulates the antitumor response of CD8+ T cells and phagocytosis of macrophages.
Periodicals：Advanced Science
IF：14.300
Article：RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer.
Periodicals：Journal of Advanced Research
IF：11.400
Article： FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Periodicals：Redox biology
IF：10.700
Article：Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m6A-YTHDF2-dependent manner.
Periodicals：Redox biology
IF：10.700
Article：m6A-modified exosome-derived circHIF1α binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia.
Periodicals：Journal of Nanobiotechnology
IF：10.600
Article：FTO-mediated SMAD2 m6A modification protects cartilage against Osteoarthritis.
Periodicals：Experimental & Molecular Medicine
IF：9.500
Article：Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.
Periodicals：Experimental & Molecular Medicine
IF：9.500
Article： Focused ultrasound combined with miR-1208-equipped exosomes inhibits malignant progression of glioma.
Periodicals：British Journal of Cancer
IF：6.400
Article：CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension.
Periodicals：Journal of the American Heart Association
IF：5.000
Article：Glycolysis Induced by METTL14 Is Essential for Macrophage Phagocytosis and Phenotype in Cervical Cancer.
Periodicals：Journal of Immunology
IF：4.400
Article：Prognostic analysis of patients with gastric cancer based on N6-methyladenosine modification patterns and tumor microenvironment characterization.
Periodicals：Frontiers in Pharmacology
IF：4.400
Article：ALKBH5-mediated upregulation of CPT1A promotes macrophage fatty acid metabolism and M2 macrophage polarization, facilitating malignant progression of colorectal cancer.
Periodicals：Experimental Cell Research
IF：3.300
【2023年】
Article：FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
Periodicals：Nature Communications
IF：17.694
Article：Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.
Periodicals：Nature Communications
IF：16.601
Article：METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
Periodicals：Cell Death and Disease
IF：9.696
Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy
Periodicals：International Journal of Biological Sciences
IF：9.200
Article：IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer
Periodicals：American Journal of Cancer Research
IF：5.300
Article：F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner
Periodicals：Cancers
IF：5.200
Article：RBM15‑mediating MDR1 mRNA m6A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer
Periodicals：International Journal of Oncology
IF：5.200
Article：FTO Sensitizes Oral Squamous Cell Carcinoma to Ferroptosis via Suppressing ACSL3 and GPX4.
Periodicals：International Journal of Molecular Sciencices
IF：4.900
Article：METTL3 exacerbates insulin resistance in hepatocytes by regulating m6A modification of cytochrome P450 2B6
Periodicals：Nutrition & Metabolism
IF：4.500
Article：METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.
Periodicals：Reproductive biology and endocrinology
IF：4.400
Article：FLOT1, stabilized by WTAP/IGF2BP2 mediated N6-methyladenosine modification, predicts poor prognosis and promotes growth and invasion in gliomas
Periodicals：Heliyon
IF：4.000
【2022年】
Article：Silencing of IRF8 Mediated by m6A Modification Promotes the Progression of T-Cell Acute Lymphoblastic Leukemia
Periodicals：Advanced Science
IF：17.521
Article：METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4
Periodicals：Leukemia
IF：12.883
Article：ALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.658
Article：AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA
Periodicals：Cell Death and Disease
IF：9.685
Article：M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
Periodicals：Cancer Science
IF：6.518
Article：The m6A Methyltransferase METTL3 Ameliorates Methylglyoxal-Induced Impairment of Insulin Secretion in Pancreatic b Cells by Regulating MafA Expression
Periodicals：Frontiers in Endocrinology
IF：6.055
Article：The m6A Methyltransferase METTL3-Mediated N6-Methyladenosine Modification of DEK mRNA to Promote Gastric Cancer Cell Growth and Metastasis
Periodicals：International Journal of Molecular Sciences
IF：5.924
Article：METTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
Periodicals：Cell Communication and Signaling
IF：5.712
Article：N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
Periodicals：Cell Death Discovery
IF：5.24
Article：Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner
Periodicals：Molecular Pain
IF：3.37
【2021年】
Article：Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m6A signaling
Periodicals：Theranostics
IF：8.578
Article：Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA
Periodicals：Frontiers in Cellular Neuroscience
IF：5.505
【2019年】
Article：Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family
Periodicals：Advanced Science
IF：17.521
