环状RNA(circRNA)过表达载体
实验介绍

伯信生物利用专利技术,成功研发出特异性准确过表达 circRNAs 的表达载体,率先为研究者提供简便高效的 circRNAs 过表达研究策略。现已推出2种 circRNAs 表达载体,适用于普通真核表达,慢病毒包装,绿色荧光和嘌呤霉素筛选等多种用途。该载体含有伯信生物专利技术的 circRNAs 环化表达框架,载体转染细胞后可通过 RNA 剪接形成 circRNAs 分子。研究者仅需以 PCR 扩增目标 circRNAs 的线性序列,克隆进表达载体中即可,大大简化实验步骤,节约时间。 (仅供科研用途)

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详细介绍

环状RNA(Circular RNAs)是广泛且多样地存在于多种生物细胞中,具有调控基因表达作用的一类内源性ncRNA分子。目前的研究中,仅仅明确了circRNA具有吸附miRNA的海绵作用、调控基因转录等作用。但是想要进一步明确circRNA在生物体内的形成机制及发挥的功能仍需要更多的circRNA相关数据来佐证。因此,circRNA过表达载体在针对circRNA功能机制的研究中起到必不可少的工具性作用。


      伯信生物利用专利技术,成功研发出特异性准确过表达circRNAs的表达载体,率先为研究者提供简便高效的circRNAs 过表达研究策略。现已推出2种circRNAs表达载体,适用于普通真核表达,慢病毒包装,绿色荧光和嘌呤霉素筛选等多种用途。该载体含有伯信生物专利技术的circRNAs环化表达框架,载体转染细胞后可通过RNA剪接形成circRNAs分子。研究者仅需以PCR扩增目标circRNAs的线性序列,克隆进表达载体中即可,大大简化实验步骤,节约时间。






升级版circRNA过表达载体新登场!


       


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                    *升级版circRNA过表达载体(质粒、慢病毒),过表达效率高达1000倍以上!环化效率高达95%!
1)过表达效率高——circRNAs 表达载体上加有伯信生物专利技术的上下游环化框架,验证过的所有 circRNAs 都能显著过表达;

2)序列环化准确——环化框架内部引入伯信生物专利技术的环化介导序列,能有效保证目标 circRNAs 的线性序列准确环化,验证过的所有 circRNAs 都能准确环化,无碱基添加或缺失现象;
3)过表达稳定性高——验证过的目标 circRNAs 从 200bp 到 2500bp 序列都能实现准确高效过表达;
4)适用范围广——适用于普通真核表达,慢病毒包装,绿色荧光和嘌呤霉素筛选等多种用途。



文章案例


【2025年】


Article:Cuticle protein mediates the evolution of stress resistance by generating a decoy circular RNA in spider mite.

Periodicals:Science Advances

IF:12.500


Article:o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis. 

Periodicals:Journal of Experimental & Clinincal Cancer Research: CR

IF:11.400


Article:MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis.

Periodicals:Translational Oncology

IF:4.500


【2024年】


Article:EIF4A3 modulated circ_000999 promotes epithelial-mesenchymal transition in cadmium-induced malignant transformation through the miR-205-5p/ZEB1 axis.

Periodicals:Environment International

IF:10.300


Article: Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis. 

Periodicals:Gene

IF:2.600


【2023年】


Article:N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.

Periodicals:Translational Neurodegeneration

IF:12.600


Article:Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis

Periodicals:Cancer Cell International

IF:5.800


【2021年】


Article:Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Periodicals:Cell Death & Disease

IF:8.469


Article:Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis

Periodicals:Cell Biology and Toxicology

IF:6.69


Article:CircRNA_0044556 diminishes the sensitivity of triple‑negative breast cancer cells to adriamycin by sponging miR‑145 and regulating NRAS

Periodicals:Molecular Medicine REPORTS

IF:2.95


Article:CircRNA hsa_circ_0005909 Promotes Cell Proliferation of Osteosarcoma Cells by Targeting miR-338-3p/HMGA1 Axis

Periodicals:Cancer Management and Research

IF:2.886


Article:Circular RNA CircCDYL Regulates Proliferation and Apoptosis in Non-Small Cell Lung Cancer Cells by Sponging miR-185-5p and Upregulating TNRC6A

Periodicals:Cancer Management and Research

IF:2.886


【2020年】


Article:CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

Periodicals:Molecular Cancer

IF:15.302


Article:Circ_2858 helps blood-brain barrier disruption by increasing VEGFA via sponging miR-93-5p during Escherichia coli meningitis

Periodicals:Molecular Therapy: Nucleic Acid

IF:7.032


Article:Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer

Periodicals:iScience

IF:4.447


Article:Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2

Periodicals:Cancer Management and Research

IF:2.886


Article:Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling

Periodicals:Cancer Management and Research

IF:2.886


【2019年】


Article:CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene

Periodicals:Annals of the Rheumatic Diseases

IF:14.299


Article:CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition

Periodicals:OncoTargets and Therapy

IF:3.337


Article:CircLMTK2 acts as a novel tumor suppressor in gastric cancer

Periodicals:Bioscience Reports

IF:2.942


【2018年】


Article:Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family

Periodicals:Advanced Science

IF:17.521


Article:Circular RNA transcriptomics analysis of primary human brain microvascular endothelial cells infected with meningitic Escherichia coli

Periodicals:Molecular Therapy: Nucleic Acid

IF:7.032


【2017年】


Article:TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway

Periodicals:Journal of Hematology & Oncology

IF:17.388