实验原理：
RIP技术运用针对目标蛋白的抗体免疫沉淀相应的RNA-蛋白复合物，并纯化与蛋白结合的RNA。最后，结合基因特异性分析技术（PCR、qRT-PCR）或高通量分析技术（高通量测序、基因芯片），分析结合在复合物上的RNA类型及数量。
产品优势：
1. 伯信独立研发。
2. 提供优化的磁珠，适于免疫沉淀RNA-蛋白复合物。
3. 高品质，稳定性好，
4. 结果准确，重复性好。
5. 操作简单，快速省时。
技术流程：
结果实例：
详见产品说明书：Bes5101 RIP(12T、24T、40T)
文章案例
【2026年】
Article：FTO-mediated m6A demethylation of CSF3 suppresses NETosis via downregulation of RLN2 expression in colorectal cancer
Periodicals：Cell Biology and Toxicology
IF：5.9003
Article：piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer
Periodicals：Molecular Cancer
IF：33.8990
Article：WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1
Periodicals：Immunity, Inflammation and Disease
IF：2.7001
Article：The RNA-binding protein MSI2 controls blood-tumor barrier permeability via LINC00667-Mediated IRF6 mRNA decay
Periodicals：The Journal of Biological Chemistry
IF：3.9003
Article：M6A modification mediates CACNA1A stability to drive the progression of ovarian cancer by inhibiting ferroptosis
Periodicals：Journal of Ovarian Research
IF：4.1998
Article：YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m5C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis
Periodicals：Investigative Ophthalmology & Visual Science
IF：4.7003
Article：Total flavonoids of Abelmoschus manihot (L.) medic attenuate early renal injury in diabetic kidney disease by modulating the LINC00665/miR-379-5p axis
Periodicals：Pharmaceutical Biology
IF：4.8003
Article：PiR48444 inhibits MSC osteogenic differentiation and bone regeneration via targeting METTL7A/eIF4E-mediated BMP2 m6A methylation
Periodicals：Communications Biology
IF：5.1000
Article：Hypoxic mesenchymal stem cell-Derived Exosomal circPTP4A2 improves granulosa cell mitochondrial function via YBX1
Periodicals：Cellular and Molecular Life Sciences
IF：6.2001
Article：Hsa_circ_PCNT sponges hsa-miR-133b to promote SHH medulloblastoma via TAGLN2
Periodicals：Cellular and Molecular Life Sciences
IF：6.2001
Article：CircPPFIA2 drives prostate cancer progression and enzalutamide resistance by sponging miR-646 and miR-1200 to upregulate ETS1
Periodicals：Cell Death Discovery
IF：6.9997
Article：FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1
Periodicals：Stem Cell Research & Therapy
IF：7.3003
Article：m6A-mediated DEC1 upregulation facilitates silica-induced pulmonary fibrosis via PI3K/Akt signaling pathway
Periodicals：Journal of Translational Medicine
IF：7.4996
Article：DNMT2 inhibits anaplastic thyroid cancer progression by downregulating 5’tiRNAGly-GCC production
Periodicals：Cell Death & Disease
IF：9.5998
Article：PXDN regulated by WTAP/YTHDF1-mediated m6A modification activates PI3K/AKT signaling pathway through extracellular matrix remodeling to promote progression in nasopharyngeal carcinoma
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.7998
Article：Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway
Periodicals：Nature Communications
IF：15.7001
Article：CircROR1 binds HNRNPL to regulate FOXO4 pre-mRNA splicing, promoting cutaneous melanoma metastasis and serving as a therapeutic target via RNAi-loaded PEG-LNPs
Periodicals：Molecular Cancer
IF：33.8990
【2025年】
Article：KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma.
Periodicals：Signal Transduction and Targeted Therapy
IF：52.700
Article：The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis.
Periodicals：Signal Transduction and Targeted Therapy
IF：52.700
Article：M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.
Periodicals：Molecular Cancer
IF：33.900
Article：CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11.
Periodicals：Molecular Cancer
IF：33.900
Article：EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/β-catenin pathway.
Periodicals：Molecular Cancer
IF：33.900
Article： m6A-modified EHD1 controls PD-L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma.
Periodicals：Cancer Communications (London, England)
IF：24.900
Article：Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.
Periodicals：Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
IF：15.800
Article：Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome.
Periodicals：Cell Death and Differentiation
IF：15.400
Article： A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis.
Periodicals：Acta Pharmceutica Sinica. B
IF：14.500
Article：ERβ/circAHNAK Axis Inhibits USP10-FMR1 Deubiquitination to Prevent m⁶A-Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma.
Periodicals：Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：METTL3/ALKBH5-Mediated N6-Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3-TASL-IRF5 Signaling Axis in Psoriasis.
Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy.
Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：LncRNA-MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid-Liquid Phase Separation.
Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.100
Article：YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in vascular smooth muscle cells.
Periodicals：Cardiovascular Research
IF：13.300
Article：RBMS1-mediates the biogenesis of circNFIB promotes perineural invasion of pancreatic ductal adenocarcinoma via the L1CAM/MAPK pathway.
Periodicals：Theranostics
IF：13.300
Article： BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner.
Periodicals：Theranostics
IF：13.300
Article：The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Periodicals：Theranostics
IF：13.300
Article：RNA binding protein RBM20 regulates turtle temperature-dependent sex determination by repressing the splicing of Wt1 KTS.
Periodicals：Science Advances
IF：12.500
Article：Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis.
Periodicals：Redox Biology
IF：11.900
Article：LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer.
Periodicals：Redox Biology
IF：11.900
Article：NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression.
Periodicals：Journal of Experimental & Clinical Cancer Research: CR
IF：11.400
Article：Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome.
Periodicals：Madcomm
IF：10.700
Article：NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.
Periodicals：Redox Biology
IF：10.700
Article：Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.
Periodicals：Redox Biology
IF：10.700
Periodicals：Engineering
IF：10.100
Periodicals：International Journal of Biological Sciences
IF：10.000
Periodicals：International Journal of Biological Sciences
IF：10.000
Periodicals：International Journal of Biological Sciences
IF：10.000
Article：XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1.
Periodicals：Cell Death & Disease
IF：9.600
Article： The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m6A methylation: a novel mechanism early during radiation-induced liver injury.
Periodicals：Cell Death & Disease
IF：9.600
Article： SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge.
Periodicals：Cellular & Molecular Biology Letters
IF：9.200
Article：RNF5 exacerbates steatotic HCC by enhancing fatty acid oxidation via the improvement of CPT1A stability.
Periodicals：Cancer Letters
IF：9.100
Article：METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Periodicals：Clinical and Translational Medicine
IF：7.900
Article：MTA1-DT promotes endometrial cancer growth by modulating G2/M-related gene transcription via PURα.
Periodicals：International Journal of Biological Macromolecules
IF：7.700
Article：Fused in Sarcoma (FUS) promotes renal cell carcinoma progression via the KCMF1/FUS/CENPT axis and activation of the JNK signaling pathway.
Periodicals：Journal of Translational Medicine
IF：7.500
Article：CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.
Periodicals：Journal of Translational Medicine
IF：7.500
Article：Correction: Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
Periodicals：Journal of Translational Medicine
IF：7.500
Article：The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation.
Periodicals：PLoS Biology
IF：7.200
Article：LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing.
Periodicals：Stem Cell Research & Therapy
IF：7.100
Article：Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.
Periodicals：Cell Death Discovery
IF：7.000
Article：Urinary exosomal lnc-TAF12-2:1 promotes bladder cancer progression through the miR-7847-3p/ASB12 regulatory axis.
Periodicals：Genes & Diseases
IF：6.900
Article：Decoding CKD-induced muscle atrophy through the critical role of lncRNA GAS5 and pyroptosis.
Periodicals：Molecular Therapy. Nucleic Acids
IF：6.500
Article： Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.
Periodicals：Journal of Translational Medicine
IF：6.100
Article：CYFIP1 coordinate with RNMT to induce osteosarcoma cuproptosis via AURKAIP1 m7G modification.
Periodicals：Molecular Medicine (Cambrige, Mass.)
IF：6.000
Article：RBM8A promotes gastric cancer progression by binding with UPF3B to induce BBC3 mRNA degradation.
Periodicals：International Journal of Molecular Medicine
IF：5.800
Article：A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability.
Periodicals：PLoS Pathogens
IF：5.500
Article：Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection.
Periodicals：PLoS Pathogens
IF：5.500
Article：The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis.
Periodicals：Cancer Cell International
IF：5.300
Article：HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability.
Periodicals：Cancer Cell International
IF：5.300
Article：A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis.
Periodicals：Communications Biology
IF：5.100
Article：PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation.
Periodicals：Communications Biology
IF：5.100
【2024年】
Article：Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.
Periodicals：Molecular cancer
IF：27.700
Article：Natural product mediated mesenchymal-epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA.
Periodicals：Acta Pharmaceutica Sinica. B
IF：14.700
Article：Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA.
Periodicals：Nature communications
IF：14.700
Article： PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer.
Periodicals：Advanced science
IF：14.300
Article： Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma.
Periodicals：Advanced science (Weinheim, Baden-Wurttemburg, Germany)
IF：14.100
Article：LncRNA BCAN-AS1 stabilizes c-Myc via N6-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.
Periodicals：Cell death and diferentiation
IF：13.700
Article：Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult.
Periodicals：Cell death and diferentiation
IF：13.700
Article：Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma.
Periodicals：Journal of experimental & clinical cancer research
IF：11.400
Article：Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism.
Periodicals：Journal of Advanced Research
IF：11.400
Article：FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Periodicals：Journal of experimental & clinical cancer research
IF：11.400
Article：Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury.
Periodicals：Redox biology
IF：10.700
Article：M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis.
Periodicals：Journal of nanobiotechnology
IF：10.600
Article：CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination.
Periodicals：Journal of nanobiotechnology
IF：10.600
Article：Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Periodicals：Environment International
IF：10.300
Article：m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.
Periodicals：Journal of Neuroinflammation
IF：9.300
Article： RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy.
Periodicals：Cellular & Molecular Biology Letters
IF：9.200
Article：NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14.
Periodicals：Cancer Letters
IF：9.100
Article：CircPCNXL2 promotes papillary thyroid carcinoma progression by regulating fatty acid metabolism induced by anabolic enzyme ACC1.
Periodicals：Cancer Letters
IF：9.100
Article：STAT6/LINC01637 axis regulates tumor growth via autophagy and pharmacological targeting STAT6 as a novel strategy for uveal melanoma.
Periodicals：Cell death & disease
IF：8.100
Article：NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair.
Periodicals：Cell death & disease
IF：8.100
Article：Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer.
Periodicals：Cell death & disease
IF：8.100
Article：The m6A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis.
Periodicals：Cell death & disease
IF：8.100
Article：N6-methyladenosine-mediated upregulation of LNCAROD confers radioresistance in esophageal squamous cell carcinoma through stabilizing PARP1.
Periodicals：Clinical and Translational Medicine
IF：7.900
Article：ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.
Periodicals：Free Radical Biology & Medicine
IF：7.100
Article：TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes.
Periodicals：Journal of medical virology
IF：6.800
Article：IGF2BP3/NCBP1 complex inhibits renal tubular senescence through regulation of CDK6 mRNA stability.
Periodicals：Translational Research
IF：6.400
Article： LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling.
Periodicals：Elife
IF：6.400
Article：LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity.
Periodicals：Cellular and Molecular Life Sciences
IF：6.200
Article：miR-148b-5p regulates hypercalciuria and calcium-containing nephrolithiasis.
Periodicals：Cellular and Molecular Life Sciences
IF：6.200
Article：miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.
Periodicals：Biology direct
IF：5.700
Article：Circ0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p. Biol Direct.
Periodicals：Biology direct
IF：5.700
Article：Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis.
Periodicals：Clinical Epigenetics
IF：5.700
Article：N6-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m6A modification in the chestnut blight fungus.
Periodicals：PLoS Pathogens
IF：5.500
Article：HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells.
Periodicals：Cell biology and Toxicology
IF：5.300
Article：Inhibition of the ATR-DNAPKcs-RB axis drives G1/S-phase transition and sensitizes triple-negative breast cancer (TNBC) to DNA holliday junctions.
Periodicals：Biochemical Pharmacology
IF：5.300
Article：circBRAF promotes the progression of triple-negative breast cancer through modulating methylation by recruiting KDM4B to histone H3K9me3 and IGF2BP3 to mRNA.
Periodicals：American Journal of Cancer Research
IF：5.300
Article：DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma.
Periodicals：Cancer Cell International
IF：5.300
Article：m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus.
Periodicals：mBio
IF：5.100
Article： circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA.
Periodicals：iScience
IF：4.600
【2023年】
Article：From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism
Periodicals：Signal Transduction and Targeted Therapy
IF：39.3
Article：CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
Periodicals：Nature Communications
IF：16.600
Article：Tumor Cell Derived Lnc-FSD2-31:1 Contributes to Cancer-Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR-4736
Periodicals：Advanced Science
IF：15.100
Article：N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop
Periodicals：Advanced Science
IF：15.100
Article：ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein
Periodicals：Advanced Science
IF：15.100
Article：Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase
Periodicals：Emerging Microbes & Infections
IF：13.200
Article：Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception
Periodicals：PNAS
IF：11.100
Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy
Periodicals：International Journal of Biological Sciences
IF：10.750
Article：Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy. J Nanobiotechnology.
Periodicals：Journal of nanobiotechnology
IF：10.600
Article：Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration
Periodicals：Clinical and Translational Medicine
IF：10.600
Article：Identification of a novel heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) ligand that disrupts HnRNPA2B1/nucleic acid interactions to inhibit the MDMX-p53 axis in gastric cancer
Periodicals：Pharmacological Research
IF：10.334
Article：CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling
Periodicals：Translational Research
IF：10.17
Article：WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis
Periodicals：Cell Death and Disease
IF：9.697
Article：METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
Periodicals：Cell Death and Disease
IF：9.696
Article：Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis
Periodicals：BMC Medicine
IF：9.300
Article： Lnc-ZEB2-19 Inhibits the Progression and Lenvatinib Resistance of Hepatocellular Carcinoma by Attenuating the NF-κB Signaling Pathway through the TRA2A/RSPH14 Axis
Periodicals：International Journal of Biological Sciences
IF：9.200
Article： N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway
Periodicals：Cell Death & Disease
IF：9.000
Article：CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification
Periodicals：Clinical and Translational Medicine
IF：8.533
Article：FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cance
Periodicals：Cell Communication and Signaling
IF：8.400
Article：Human Keratinocyte-Derived Exosomal MALAT1 Promotes Diabetic Wound Healing by Upregulating MFGE8 via microRNA-1914-3p
Periodicals：International Journal of Nanomedicine
IF：7.033
Article：A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis.
Periodicals：Cell Death Discovery
IF：7.000
Article：METTL3-mediated m6A methylation of C1qA regulates the Rituximab resistance of diffuse large B-cell lymphoma cells.
Periodicals：Cell Death Discovery
IF：7.000
Article：Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis
Periodicals：Cancers
IF：6.575
Article：circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep
Periodicals：International Journal of Molecular Sciences
IF：6.208
Article：lncRNA HCG11 suppresses cell proliferation in hormone receptorpositive breast cancer via SRSF1/β-catenin
Periodicals：Aging
IF：5.956
Article：circIFNGR2 regulating ankylosing spondylitis-associated inflammation through macrophage polarization
Periodicals：iScience
IF：5.800
Article：Circular Intronic RNA circTTN Inhibits Host Gene Transcription and Myogenesis by Recruiting PURB Proteins to form Heterotypic Complexes
Periodicals：International Journal of Molecular Sciences
IF：5.600
Article：Overexpression of FTO inhibits excessive proliferation and promotes the apoptosis of human glomerular mesangial cells by alleviating FOXO6 m6A modification via YTHDF3-dependent mechanisms
Periodicals：Frontiers in Pharmacology
IF：5.5999
Article：Interaction of Teleost Fish TRPV4 with DEAD Box RNA Helicase 1 Regulates Iridovirus Replication
Periodicals：Journal of Virology
IF：5.3999
Article：IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer
Periodicals：American Journal of Cancer Research
IF：5.300
Article：Pro-fbrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury
Periodicals：European Journal of Medical Research
IF：4.981
Article：CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
Periodicals：Arthritis Research & Therapy
IF：4.900
Article：METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis
Periodicals：Epigenetics
IF：4.861
Article：LncRNA TUG1 promotes pulmonary fibrosis progression via up-regulating CDC27 and activating PI3K/Akt/mTOR pathway
Periodicals：Epigenetics
IF：4.861
Article：eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation
Periodicals：Jounal of Biological Chemistry
IF：4.800
Article：IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation
Periodicals：Cancer Medicine
IF：4.711
Article：Gemcitabine Inhibits the Progression of Pancreatic Cancer by Restraining the WTAP/MYC Chain in an m6A-Dependent Manner.
Periodicals：Cancer research and treatment
IF：4.600
Article：METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.
Periodicals：Reproductive biology and endocrinology
IF：4.400
Article：RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression
Periodicals：Oncology Reports
IF：4.200
Article：YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation
Periodicals：Heliyon
IF：4.000
Article：LINC00955 suppresses colorectal cancer growth by acting as a molecular scaffold of TRIM25 and Sp1 to Inhibit DNMT3B-mediated methylation of the PHIP promoter
Periodicals：BMC Cancer
IF：3.800
Article：Exploring the regulatory role of Linc00893 in asthenozoospermia: Insights into sperm motility and SSC viability.
Periodicals：Molecular medicine reports
IF：3.400
【2022年】
Periodicals：Molecular Therapy
IF：12.91
Article：STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.658
Article：ALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.658
Article：PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer
Periodicals：International Journal of Biological Sciences
IF：10.75
Article：Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis
Periodicals：Cell Death and Disease
IF：9.685
Article：Hotair promotes the migration and proliferation in ovarian cancer by miR‑222‑3p/CDK19 axis
Periodicals：Cellular and Molecular Life Sciences
IF：9.26
Article：Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer
Periodicals：Cancer Letters
IF：8.697
Article：circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3
Periodicals：Biomarker Research
IF：8.633
Article：circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma
Periodicals：Experimental Hematology & Oncology
IF：8.593
Article：YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis
Periodicals：Cell Death & Disease
IF：8.469
Article：circCRKL, a circRNA derived from CRKL,regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation
Periodicals：Journal of Translational Medicine
IF：8.439
Article：PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62
Periodicals：Cells
IF：7.666
Article：Interaction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors
Periodicals：PLOS Pathogens
IF：7.455
Article：A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic infammatory microenvironment
Periodicals：Stem Cell Research & Therapy
IF：6.832
Article：Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a
Periodicals：Bioengineered
IF：6.832
Article：FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2
Periodicals：Cancers
IF：6.575
Article：M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
Periodicals：Cancer Science
IF：6.518
Article：LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation
Periodicals：Molecular Medicine
IF：6.376
Article：Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome
Periodicals：Frontiers in Cellular Neuroscience
IF：6.146
Article：CircMYH9 increases KPNA2 mRNA stability to promote hepatocellular carcinoma progression in an EIF4A3-dependent manner
Periodicals：American journal of cancer research
IF：5.942
Article：SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells
Periodicals：Cellular & Molecular Biology Letters
IF：5.78
Article：METTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
Periodicals：Cell Communication and Signaling
IF：5.712
Article：CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer
Periodicals：Cell Death Discovery
IF：5.24
Article：EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway
Periodicals：Cell Death Discovery
IF：5.24
Article：Long noncoding RNA LINC00518 contributes to proliferation and metastasis in lung adenocarcinoma via the miR-335-3p/CTHRC1 Axis
Periodicals：Cell Death Discovery
IF：5.24
Article：Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p
Periodicals：Cell Death Discovery
IF：5.24
Article：CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway
Periodicals：Cell Death Discovery
IF：5.24
Article：IGF2BP3 enhances the mRNA stability of E2F3 by interacting with LINC00958 to promote endometrial carcinoma progression
Periodicals：Cell Death Discovery
IF：5.24
Article：LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia
Periodicals：Scientifc Reports
IF：4.996
Article：Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury
Periodicals：Central European Journal of Immunology
IF：4.39
Article：Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8
Periodicals：Thorac Cancer
IF：3.5
Article：LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis
Periodicals：Disease Markers
IF：3.464
Article：Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a
Periodicals：Bioengineered
IF：3.269
【2021年】
Article：NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1
Periodicals：Signal Transduction and Targeted Therapy
IF：13.493
Article：Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β
Periodicals：Clinical and Translational Medicine
IF：11.492
Article：LINC00473-modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid-induced osteonecrosis of femoral head: A detailed mechanistic study and validity evaluation
Periodicals：Bioengineering & Translational Medicine
IF：10.711
Article：HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer
Periodicals：Molecular Therapy-Nucleic Acids
IF：8.886
Article：hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3
Periodicals：Molecular Therapy-Nucleic Acids
IF：8.886
Article：CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944
Periodicals：Cell Death & Disease
IF：8.469
Article：LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity
Periodicals：Cell Death & Disease
IF：8.469
Article：LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer
Periodicals：Cell Death & Disease
IF：8.469
Article：LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma
Periodicals：Cell Death & Disease
IF：8.469
Article：Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：7.038
Article：SAFA initiates innate immunity against cytoplasmic RNA virus SFTSV infection
Periodicals：PLOS Pathogens
IF：6.823
Article：Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription
Periodicals：Am J Cancer Res
IF：5.884
Article：RPL34-AS1–induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway
Periodicals：Cancer Science
IF：4.966
Article：Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7
Periodicals：Genes
IF：3.757
Article：Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance
Periodicals：Technology in Cancer Research & Treatment
IF：3.399
Article：A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells
Periodicals：Bioengineered
IF：3.268
【2020年】
Article：LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling
Periodicals：Theranostics
IF：8.698
Article：Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation
Periodicals：Stem Cell Research & Therapy
IF：5.081
Article：Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1
Periodicals：Cancer Science
IF：4.985
Article：Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer
Periodicals：iScience
IF：4.447
Article：LINC00689 promotes prostate cancer progression via regulating miR-496/CTNNB1 to activate Wnt pathway
Periodicals：Cancer Cell International
IF：3.991
Article：CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p
Periodicals：OncoTargets and Therapy
IF：3.259
【2019年】
Article：CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：7.038
Article：PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression
Periodicals：Cell Death & Disease
IF：6.28
Article：Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2
Periodicals：Clinical Epigenetics
IF：5.156
Article：CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression
Periodicals：Frontiers in Oncology
IF：4.137
【2017年】
Article：LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1
Periodicals：Journal of Cellular and Molecular Medicine
IF：4.302
