实验原理：



RIP技术运用针对目标蛋白的抗体免疫沉淀相应的RNA-蛋白复合物，并纯化与蛋白结合的RNA。最后，结合基因特异性分析技术（PCR、qRT-PCR）或高通量分析技术（高通量测序、基因芯片），分析结合在复合物上的RNA类型及数量。

 

产品优势：



1. 伯信独立研发。

2. 提供优化的磁珠，适于免疫沉淀RNA-蛋白复合物。

3. 高品质，稳定性好，

4. 结果准确，重复性好。

5. 操作简单，快速省时。



技术流程：





结果实例：





详见产品说明书：Bes5101 RIP(12T、24T、40T)



文章案例

【2026年】

Article：TENT5A Maintains MYC mRNA Stability to Enhance Osteosarcoma Stemness

Periodicals：Cancer Research

IF：16.6

 

Article：hnRNPM cooperates with BCAS2 to modulate alternative splicing during oocyte

Periodicals：Nature Communications

IF：15.7001

 

Article：Astrocytic TIA1-Mediated Stress Granules Promote the Demyelination of Optic Neuritis

Periodicals：Advanced Science

IF：14.1006

 

Article：Cannabidiol triggers fatty acids β-oxidation mediated by Stat2

Periodicals：Experimental & Molecular Medicine

IF：12.9

 

Article：Oxidative stress-driven m5 C methylation by NSUN5 confers cisplatin resistance

Periodicals：Redox Biology

IF：11.9

 

Article：Y chromosome-linked EIF1AY deletion drives sex differencesinmultiplemyeloma

Periodicals：npj Precision Oncology

IF：8.000

 

Article：DKC1 a robust prognostic factor and potential therapeutic target in multiple myeloma

Periodicals：Journal of Translational Medicine

IF：7.4996

 

Article：NAT10 promotes gallbladder cancer progression by remodeling cholesterol metabolism

Periodicals：Cell Death Discovery

IF：7.0

 

Article：SERBP1 is required for efficient HR repair and cisplatin chemoresistance

Periodicals：Cell Death Discovery

IF：6.9997

 

Article：A Novel circRERE miR-27a-3p Caspase9 Signaling Axis Promotes Cardiomyocyte

Periodicals：Cells

IF：5.2

 

Article：The ZNF148 ZEB1 AS1 IGF2BP2 NOD2 Axis Drives Microglial Antipneumococcal Immunity

Periodicals：GLIA

IF：5.1000

 

Article：A dynamic DiflncRNA-CR42715miR-965-3p

Periodicals：PLoS Pathogens

IF：4.9000

 

Article：Anzi Tiaochong Tang inhibits

Periodicals：Frontiers in Pharmacology

IF：4.8

 

Article：Pyrimethamine regulates m6A modification of CCND1 via METTL14YTHDF2 to inhibit hepatocellular carcinoma

Periodicals：Bioorganic Chemistry

IF：4.7

 

Article：A Novel Long Noncoding RNA–LNC000133 Associated

Periodicals：Journal of Cellular and Molecular Medicine

IF：4.1998

 

Article：Exosomes-Transferred lncRNA H19 Reverses Osimertinib Resistance by Upregulating

Periodicals：Oncology Research

IF：4.1

 

Article：CircNOLC1KRT16 promotes colorectal cancer invasion and migration

Periodicals：Journal of Biological Chemistry

IF：3.9

 

Article：YTHDF1 impacts cardiomyocyte differentiation by regulating the TET2 mRNA

Periodicals：PLOS ONE

IF：2.6

Article：FTO-mediated m6A demethylation of CSF3 suppresses NETosis via downregulation of RLN2 expression in colorectal cancer
Periodicals：Cell Biology and Toxicology
IF：5.9003

 

Article：piR-1170 drives brain metastasis and immune evasion via WTAP-mediated m6A methylation reprogramming in triple-negative breast cancer
Periodicals：Molecular Cancer
IF：33.8990

 

Article：WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1
Periodicals：Immunity, Inflammation and Disease
IF：2.7001

 

Article：The RNA-binding protein MSI2 controls blood-tumor barrier permeability via LINC00667-Mediated IRF6 mRNA decay
Periodicals：The Journal of Biological Chemistry
IF：3.9003

 

Article：M6A modification mediates CACNA1A stability to drive the progression of ovarian cancer by inhibiting ferroptosis
Periodicals：Journal of Ovarian Research
IF：4.1998

 

Article：YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m5C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis
Periodicals：Investigative Ophthalmology & Visual Science
IF：4.7003

 

Article：Total flavonoids of Abelmoschus manihot (L.) medic attenuate early renal injury in diabetic kidney disease by modulating the LINC00665/miR-379-5p axis
Periodicals：Pharmaceutical Biology
IF：4.8003

 

Article：PiR48444 inhibits MSC osteogenic differentiation and bone regeneration via targeting METTL7A/eIF4E-mediated BMP2 m6A methylation
Periodicals：Communications Biology
IF：5.1000

 

Article：Hypoxic mesenchymal stem cell-Derived Exosomal circPTP4A2 improves granulosa cell mitochondrial function via YBX1
Periodicals：Cellular and Molecular Life Sciences
IF：6.2001

 

Article：Hsa_circ_PCNT sponges hsa-miR-133b to promote SHH medulloblastoma via TAGLN2
Periodicals：Cellular and Molecular Life Sciences
IF：6.2001

 

Article：CircPPFIA2 drives prostate cancer progression and enzalutamide resistance by sponging miR-646 and miR-1200 to upregulate ETS1
Periodicals：Cell Death Discovery
IF：6.9997

 

Article：FTO-mediated m6A modification regulates the osteogenic differentiation of ADSCs by targeting FOXO1
Periodicals：Stem Cell Research & Therapy
IF：7.3003

 

Article：m6A-mediated DEC1 upregulation facilitates silica-induced pulmonary fibrosis via PI3K/Akt signaling pathway
Periodicals：Journal of Translational Medicine
IF：7.4996

 

Article：DNMT2 inhibits anaplastic thyroid cancer progression by downregulating 5’tiRNAGly-GCC production
Periodicals：Cell Death & Disease
IF：9.5998

 

Article：PXDN regulated by WTAP/YTHDF1-mediated m6A modification activates PI3K/AKT signaling pathway through extracellular matrix remodeling to promote progression in nasopharyngeal carcinoma
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：12.7998

 

Article：Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway
Periodicals：Nature Communications
IF：15.7001

 

Article：CircROR1 binds HNRNPL to regulate FOXO4 pre-mRNA splicing, promoting cutaneous melanoma metastasis and serving as a therapeutic target via RNAi-loaded PEG-LNPs
Periodicals：Molecular Cancer
IF：33.8990


【2025年】




Article：KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma. 

Periodicals：Signal Transduction and Targeted Therapy

IF：52.700




Article：The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis.

Periodicals：Signal Transduction and Targeted Therapy

IF：52.700




Article：M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression. 

Periodicals：Molecular Cancer

IF：33.900




Article：CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11.

Periodicals：Molecular Cancer

IF：33.900




Article：EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/β-catenin pathway.

Periodicals：Molecular Cancer

IF：33.900



Article： m6A-modified EHD1 controls PD-L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma. 

Periodicals：Cancer Communications (London, England)

IF：24.900



Article：Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer.

Periodicals：Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

IF：15.800



Article：Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome.

Periodicals：Cell Death and Differentiation

IF：15.400



Article： A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis. 

Periodicals：Acta Pharmceutica Sinica. B

IF：14.500



Article：ERβ/circAHNAK Axis Inhibits USP10-FMR1 Deubiquitination to Prevent m⁶A-Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma. 

Periodicals：Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

IF：14.100



Article：METTL3/ALKBH5-Mediated N6-Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3-TASL-IRF5 Signaling Axis in Psoriasis. 

Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)

IF：14.100



Article：SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy.

Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)

IF：14.100



Article：Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway. 

Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)

IF：14.100



Article：LncRNA-MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid-Liquid Phase Separation. 

Periodicals：Advance Science (Weinheim, Baden-Wurttemberg, Germany)

IF：14.100



Article：YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in vascular smooth muscle cells.

Periodicals：Cardiovascular Research

IF：13.300



Article：RBMS1-mediates the biogenesis of circNFIB promotes perineural invasion of pancreatic ductal adenocarcinoma via the L1CAM/MAPK pathway.

Periodicals：Theranostics

IF：13.300



Article： BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner.

Periodicals：Theranostics

IF：13.300



Article：The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy. 

Periodicals：Theranostics

IF：13.300



Article：RNA binding protein RBM20 regulates turtle temperature-dependent sex determination by repressing the splicing of Wt1 KTS.

Periodicals：Science Advances

IF：12.500



Article：Clock gene ARNTL2 enhances 5-fluorouracil resistance in colon cancer by upregulating SLC7A11 to suppress ferroptosis. 

Periodicals：Redox Biology

IF：11.900



Article：LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer. 

Periodicals：Redox Biology

IF：11.900



Article：NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression. 

Periodicals：Journal of Experimental & Clinical Cancer Research: CR

IF：11.400



Article：Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome.

Periodicals：Madcomm

IF：10.700




Article：NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.

Periodicals：Redox Biology

IF：10.700




Article：Liraglutide and GLP-1(9-37) alleviated hepatic ischemia-reperfusion injury by inhibiting ferroptosis via GSK3β/Nrf2 pathway and SMAD159/Hepcidin/FTH pathway.

Periodicals：Redox Biology

IF：10.700




Article：Increased Alleviation of Bone Destruction in Individuals with Rheumatoid Arthritis via the Coinhibition of the METTL3 and YTHDF1 Axis by the Combination of Triptolide and Medicarpin
Periodicals：Engineering

IF：10.100



Article：Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury.
Periodicals：International Journal of Biological  Sciences

IF：10.000



Article：Targeting the NAT10/XIST/YAP1 Axis-Mediated Vascular Abnormalization Enhances Immune Checkpoint Blockade in Gastric Cancer. 
Periodicals：International Journal of Biological Sciences

IF：10.000



Article：CircMVP promotes METTL3 activation mediated CTNNB1 m6A modification in the inhibition of colorectal cancer in B7-H3 dependence antitumor immunity.
Periodicals：International Journal of Biological Sciences

IF：10.000



Article：XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1.

Periodicals：Cell Death & Disease

IF：9.600



Article： The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m6A methylation: a novel mechanism early during radiation-induced liver injury. 

Periodicals：Cell Death & Disease

IF：9.600



Article： SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge.

Periodicals：Cellular & Molecular Biology Letters

IF：9.200




Article：RNF5 exacerbates steatotic HCC by enhancing fatty acid oxidation via the improvement of CPT1A stability. 

Periodicals：Cancer Letters

IF：9.100




Article：METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination. 

Periodicals：Clinical and Translational Medicine

IF：7.900



Article：MTA1-DT promotes endometrial cancer growth by modulating G2/M-related gene transcription via PURα. 

Periodicals：International Journal of Biological Macromolecules

IF：7.700



Article：Fused in Sarcoma (FUS) promotes renal cell carcinoma progression via the KCMF1/FUS/CENPT axis and activation of the JNK signaling pathway.

Periodicals：Journal of Translational Medicine

IF：7.500



Article：CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.

Periodicals：Journal of Translational Medicine

IF：7.500



Article：Correction: Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1. 

Periodicals：Journal of Translational Medicine

IF：7.500



Article：The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation. 

Periodicals：PLoS Biology

IF：7.200



Article：LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing. 

Periodicals：Stem Cell Research & Therapy

IF：7.100



Article：Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.

Periodicals：Cell Death Discovery

IF：7.000



Article：Urinary exosomal lnc-TAF12-2:1 promotes bladder cancer progression through the miR-7847-3p/ASB12 regulatory axis. 

Periodicals：Genes & Diseases

IF：6.900



Article：Decoding CKD-induced muscle atrophy through the critical role of lncRNA GAS5 and pyroptosis. 

Periodicals：Molecular Therapy. Nucleic Acids

IF：6.500



Article： Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1.

Periodicals：Journal of Translational Medicine

IF：6.100



Article：CYFIP1 coordinate with RNMT to induce osteosarcoma cuproptosis via AURKAIP1 m7G modification.

Periodicals：Molecular Medicine (Cambrige, Mass.)

IF：6.000



Article：RBM8A promotes gastric cancer progression by binding with UPF3B to induce BBC3 mRNA degradation. 

Periodicals：International Journal of Molecular Medicine

IF：5.800



Article：A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability.

Periodicals：PLoS Pathogens

IF：5.500




Article：Small interfering RNAs generated from the terminal panhandle structure of negative-strand RNA virus promote viral infection. 

Periodicals：PLoS Pathogens

IF：5.500



Article：The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis.

Periodicals：Cancer Cell International

IF：5.300



Article：HNRNPC promotes progression of non-small cell lung cancer by maintaining TFAP2A mRNA stability. 

Periodicals：Cancer Cell International

IF：5.300



Article：A-to-I edited SNHG3 promotes non-small cell lung cancer metastasis by promoting fatty acid oxidation and resisting ferroptosis. 

Periodicals：Communications Biology

IF：5.100



Article：PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation.

Periodicals：Communications Biology

IF：5.100




【2024年】




Article：Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway.

Periodicals：Molecular cancer

IF：27.700



Article：Natural product mediated mesenchymal-epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA.

Periodicals：Acta Pharmaceutica Sinica. B

IF：14.700



Article：Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA.

Periodicals：Nature communications

IF：14.700




Article： PTBP3 Mediates IL-18 Exon Skipping to Promote Immune Escape in Gallbladder Cancer.

Periodicals：Advanced science

IF：14.300



Article： Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma. 

Periodicals：Advanced science (Weinheim, Baden-Wurttemburg, Germany)

IF：14.100



Article：LncRNA BCAN-AS1 stabilizes c-Myc via N6-methyladenosine-mediated binding with SNIP1 to promote pancreatic cancer.

Periodicals：Cell death and diferentiation

IF：13.700



Article：Cold-inducible RNA binding protein alleviates iron overload-induced neural ferroptosis under perinatal hypoxia insult.
Periodicals：Cell death and diferentiation

IF：13.700



Article：Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma. 

Periodicals：Journal of experimental & clinical cancer research

IF：11.400




Article：Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism.

Periodicals：Journal of Advanced Research

IF：11.400




Article：FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer. 

Periodicals：Journal of experimental & clinical cancer research

IF：11.400



Article：Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury. 

Periodicals：Redox biology

IF：10.700



Article：M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis. 

Periodicals：Journal of nanobiotechnology

IF：10.600



Article：CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination.

Periodicals：Journal of nanobiotechnology

IF：10.600




Article：Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels. 

Periodicals：Environment International

IF：10.300



Article：m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells. 

Periodicals：Journal of Neuroinflammation

IF：9.300




Article： RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy. 

Periodicals：Cellular & Molecular Biology Letters

IF：9.200




Article：NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14. 

Periodicals：Cancer Letters

IF：9.100



Article：CircPCNXL2 promotes papillary thyroid carcinoma progression by regulating fatty acid metabolism induced by anabolic enzyme ACC1. 

Periodicals：Cancer Letters

IF：9.100



Article：STAT6/LINC01637 axis regulates tumor growth via autophagy and pharmacological targeting STAT6 as a novel strategy for uveal melanoma. 

Periodicals：Cell death & disease

IF：8.100



Article：NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair.

Periodicals：Cell death & disease

IF：8.100



Article：Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer. 

Periodicals：Cell death & disease

IF：8.100




Article：The m6A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis. 

Periodicals：Cell death & disease

IF：8.100



Article：N6-methyladenosine-mediated upregulation of LNCAROD confers radioresistance in esophageal squamous cell carcinoma through stabilizing PARP1. 

Periodicals：Clinical and Translational Medicine

IF：7.900



Article：ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.

Periodicals：Free Radical Biology & Medicine

IF：7.100



Article：TRIM6 facilitates SARS-CoV-2 proliferation by catalyzing the K29-typed ubiquitination of NP to enhance the ability to bind viral genomes. 

Periodicals：Journal of medical virology

IF：6.800




Article：IGF2BP3/NCBP1 complex inhibits renal tubular senescence through regulation of CDK6 mRNA stability.

Periodicals：Translational Research

IF：6.400



Article： LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling. 

Periodicals：Elife

IF：6.400




Article：LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity. 

Periodicals：Cellular and Molecular Life Sciences

IF：6.200



Article：miR-148b-5p regulates hypercalciuria and calcium-containing nephrolithiasis.

Periodicals：Cellular and Molecular Life Sciences

IF：6.200



Article：miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization.

Periodicals：Biology direct

IF：5.700




Article：Circ0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p. Biol Direct. 

Periodicals：Biology direct

IF：5.700




Article：Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis.

Periodicals：Clinical Epigenetics

IF：5.700




Article：N6-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m6A modification in the chestnut blight fungus.

Periodicals：PLoS Pathogens

IF：5.500




Article：HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells. 

Periodicals：Cell biology and Toxicology

IF：5.300





Article：Inhibition of the ATR-DNAPKcs-RB axis drives G1/S-phase transition and sensitizes triple-negative breast cancer (TNBC) to DNA holliday junctions.

Periodicals：Biochemical Pharmacology

IF：5.300



Article：circBRAF promotes the progression of triple-negative breast cancer through modulating methylation by recruiting KDM4B to histone H3K9me3 and IGF2BP3 to mRNA. 

Periodicals：American Journal of Cancer Research

IF：5.300



Article：DUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma. 

Periodicals：Cancer Cell International

IF：5.300



Article：m6A demethylase CpALKBH regulates CpZap1 mRNA stability to modulate the development and virulence of chestnut blight fungus. 

Periodicals：mBio

IF：5.100



Article： circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA.

Periodicals：iScience

IF：4.600



【2023年】




Article：From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism

Periodicals：Signal Transduction and Targeted Therapy

IF：39.3



Article：CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications

Periodicals：Nature Communications

IF：16.600



Article：Tumor Cell Derived Lnc-FSD2-31:1 Contributes to Cancer-Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR-4736

Periodicals：Advanced Science

IF：15.100



Article：N4-Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF-1α Positive Feedback Loop

Periodicals：Advanced Science

IF：15.100




Article：ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein

Periodicals：Advanced Science

IF：15.100



Article：Identification of TMEM53 as a novel SADS-CoV restriction factor that targets viral RNA-dependent RNA polymerase

Periodicals：Emerging Microbes & Infections

IF：13.200




Article：Harnessing endogenous transcription factors directly by small molecules for chemically induced pluripotency inception

Periodicals：PNAS

IF：11.100




Article：M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy

Periodicals：International Journal of Biological Sciences

IF：10.750



Article：Intervening in hnRNPA2B1-mediated exosomal transfer of tumor-suppressive miR-184-3p for tumor microenvironment regulation and cancer therapy. J Nanobiotechnology. 

Periodicals：Journal of nanobiotechnology

IF：10.600



Article：Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration

Periodicals：Clinical and Translational Medicine

IF：10.600



Article：Identification of a novel heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) ligand that disrupts HnRNPA2B1/nucleic acid interactions to inhibit the MDMX-p53 axis in gastric cancer

Periodicals：Pharmacological Research

IF：10.334



Article：CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling


Periodicals：Translational Research

IF：10.17



Article：WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis

Periodicals：Cell Death and Disease

IF：9.697



Article：METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer

Periodicals：Cell Death and Disease

IF：9.696



Article：Downregulation of AC092894.1 promotes oxaliplatin resistance in colorectal cancer via the USP3/AR/RASGRP3 axis

Periodicals：BMC Medicine

IF：9.300



Article： Lnc-ZEB2-19 Inhibits the Progression and Lenvatinib Resistance of Hepatocellular Carcinoma by Attenuating the NF-κB Signaling Pathway through the TRA2A/RSPH14 Axis

Periodicals：International Journal of Biological Sciences

IF：9.200



Article： N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway

Periodicals：Cell Death & Disease

IF：9.000



Article：CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification

Periodicals：Clinical and Translational Medicine

IF：8.533



Article：FTO facilitates cancer metastasis by modifying the m6A level of FAP to induce integrin/FAK signaling in non-small cell lung cance

Periodicals：Cell Communication and Signaling

IF：8.400



Article：Human Keratinocyte-Derived Exosomal MALAT1 Promotes Diabetic Wound Healing by Upregulating MFGE8 via microRNA-1914-3p

Periodicals：International Journal of Nanomedicine

IF：7.033



Article：A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis.

Periodicals：Cell Death Discovery

IF：7.000



Article：METTL3-mediated m6A methylation of C1qA regulates the Rituximab resistance of diffuse large B-cell lymphoma cells.

Periodicals：Cell Death Discovery

IF：7.000



Article：Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis

Periodicals：Cancers

IF：6.575



Article：circINSR Inhibits Adipogenic Differentiation of Adipose-Derived Stromal Vascular Fractions through the miR-152/MEOX2 Axis in Sheep

Periodicals：International Journal of Molecular Sciences

IF：6.208




Article：lncRNA HCG11 suppresses cell proliferation in hormone receptorpositive breast cancer via SRSF1/β-catenin

Periodicals：Aging

IF：5.956



Article：circIFNGR2 regulating ankylosing spondylitis-associated inflammation through macrophage polarization



Periodicals：iScience

IF：5.800




Article：Circular Intronic RNA circTTN Inhibits Host Gene Transcription and Myogenesis by Recruiting PURB Proteins to form Heterotypic Complexes

Periodicals：International Journal of Molecular Sciences

IF：5.600



Article：Overexpression of FTO inhibits excessive proliferation and promotes the apoptosis of human glomerular mesangial cells by alleviating FOXO6 m6A modification via YTHDF3-dependent mechanisms

Periodicals：Frontiers in Pharmacology

IF：5.5999



Article：Interaction of Teleost Fish TRPV4 with DEAD Box RNA Helicase 1 Regulates Iridovirus Replication

Periodicals：Journal of Virology

IF：5.3999




Article：IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer

Periodicals：American Journal of Cancer Research

IF：5.300



Article：Pro-fbrotic and apoptotic activities of circARAP1 in myocardial ischemia–reperfusion injury

Periodicals：European Journal of Medical Research

IF：4.981



Article：CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus

Periodicals：Arthritis Research & Therapy

IF：4.900



Article：METTL3-mediated m6A modification of lnc KCNQ1OT1 promotes doxorubicin resistance in breast cancer by regulating miR-103a-3p/MDR1 axis

Periodicals：Epigenetics

IF：4.861




Article：LncRNA TUG1 promotes pulmonary fibrosis progression via up-regulating CDC27 and activating PI3K/Akt/mTOR pathway

Periodicals：Epigenetics

IF：4.861



Article：eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation

Periodicals：Jounal of Biological Chemistry

IF：4.800



Article：IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation

Periodicals：Cancer Medicine

IF：4.711




Article：Gemcitabine Inhibits the Progression of Pancreatic Cancer by Restraining the WTAP/MYC Chain in an m6A-Dependent Manner. 

Periodicals：Cancer research and treatment

IF：4.600




Article：METTL3-regulated m6A modification impairs the decidualization of endometrial stromal cells by regulating YTHDF2-mediated degradation of FOXO1 mRNA in endometriosis-related infertility.

Periodicals：Reproductive biology and endocrinology

IF：4.400




Article：RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression

Periodicals：Oncology Reports

IF：4.200




Article：YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation

Periodicals：Heliyon

IF：4.000




【2022年】



Article：The short inverted repeats-induced circEXOC6B inhibits prostate cancer metastasis by enhancing the binding of RBMS1 and HuR
Periodicals：Molecular Therapy

IF：12.91



Article：STAT3/miR-130b-3p/MBNL1 feedback loop regulated by mTORC1 signaling promotes angiogenesis and tumor growth


Periodicals：Journal of Experimental & Clinical Cancer Research

IF：12.658



Article：ALKBH5-mediated m6A modifcation of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription

Periodicals：Journal of Experimental & Clinical Cancer Research

IF：12.658



Article：PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer

Periodicals：International Journal of Biological Sciences

IF：10.75



Article：Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis

Periodicals：Cell Death and Disease

IF：9.685



Article：Hotair promotes the migration and proliferation in ovarian cancer by miR‑222‑3p/CDK19 axis

Periodicals：Cellular and Molecular Life Sciences

IF：9.26



Article：Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer

Periodicals：Cancer Letters

IF：8.697



Article：circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3

Periodicals：Biomarker Research

IF：8.633




Article：circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma

Periodicals：Experimental Hematology & Oncology

IF：8.593



Article：YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis

Periodicals：Cell Death & Disease

IF：8.469



Article：circCRKL, a circRNA derived from CRKL,regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation

Periodicals：Journal of Translational Medicine

IF：8.439




Article：PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62

Periodicals：Cells

IF：7.666



Article：Interaction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors

Periodicals：PLOS Pathogens

IF：7.455



Article：A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic infammatory microenvironment

Periodicals：Stem Cell Research & Therapy

IF：6.832




Article：Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a

Periodicals：Bioengineered

IF：6.832




Article：FTO Inhibits Epithelial Ovarian Cancer Progression by Destabilising SNAI1 mRNA through IGF2BP2

Periodicals：Cancers

IF：6.575



Article：M6A demethylase fat mass and obesity-associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1

Periodicals：Cancer Science

IF：6.518



Article：LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation

Periodicals：Molecular Medicine

IF：6.376




Article：Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome

Periodicals：Frontiers in Cellular Neuroscience

IF：6.146



Article：CircMYH9 increases KPNA2 mRNA stability to promote hepatocellular carcinoma progression in an EIF4A3-dependent manner

Periodicals：American journal of cancer research

IF：5.942



Article：SNHG3 could promote prostate cancer progression through reducing methionine dependence of PCa cells

Periodicals：Cellular & Molecular Biology Letters

IF：5.78



Article：METTL14-mediated N6-methyladenosine modifcation of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma

Periodicals：Cell Communication and Signaling

IF：5.712



Article：CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer

Periodicals：Cell Death Discovery

IF：5.24



Article：EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway

Periodicals：Cell Death Discovery

IF：5.24



Article：Long noncoding RNA LINC00518 contributes to proliferation and metastasis in lung adenocarcinoma via the miR-335-3p/CTHRC1 Axis

Periodicals：Cell Death Discovery

IF：5.24



Article：Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p

Periodicals：Cell Death Discovery

IF：5.24



Article：CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway

Periodicals：Cell Death Discovery

IF：5.24



Article：IGF2BP3 enhances the mRNA stability of E2F3 by interacting with LINC00958 to promote endometrial carcinoma progression

Periodicals：Cell Death Discovery

IF：5.24




Article：LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia

Periodicals：Scientifc Reports

IF：4.996



Article：Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury

Periodicals：Central European Journal of Immunology

IF：4.39




Article：LINC01140 Targeting miR-452-5p/RGS2 Pathway to Attenuate Breast Cancer Tumorigenesis

Periodicals：Disease Markers

IF：3.464



Article：Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a

Periodicals：Bioengineered

IF：3.269



【2021年】




Article：NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1

Periodicals：Signal Transduction and Targeted Therapy

IF：13.493



Article：Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3β


Periodicals：Clinical and Translational Medicine

IF：11.492



Article：LINC00473-modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid-induced osteonecrosis of femoral head: A detailed mechanistic study and validity evaluation

Periodicals：Bioengineering & Translational Medicine

IF：10.711



Article：HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer

Periodicals：Molecular Therapy-Nucleic Acids

IF：8.886



Article：hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3

Periodicals：Molecular Therapy-Nucleic Acids

IF：8.886



Article：CircHAS2 promotes the proliferation, migration, and invasion of gastric cancer cells by regulating PPM1E mediated by hsa-miR-944

Periodicals：Cell Death & Disease

IF：8.469



Article：LncRNA H19 governs mitophagy and restores mitochondrial respiration in the heart through Pink1/Parkin signaling during obesity

Periodicals：Cell Death & Disease

IF：8.469



Article：LINC-PINT impedes DNA repair and enhances radiotherapeutic response by targeting DNA-PKcs in nasopharyngeal cancer

Periodicals：Cell Death & Disease

IF：8.469



Article：LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma

Periodicals：Cell Death & Disease

IF：8.469




Article：Lnc-GAN1 expression is associated with good survival and suppresses tumor progression by sponging mir-26a-5p to activate PTEN signaling in non-small cell lung cancer

Periodicals：Journal of Experimental & Clinical Cancer Research

IF：7.038



Article：SAFA initiates innate immunity against cytoplasmic RNA virus SFTSV infection

Periodicals：PLOS Pathogens

IF：6.823



Article：Epigenetically silenced linc00261 contributes to the metastasis of hepatocellular carcinoma via inducing the deficiency of FOXA2 transcription

Periodicals：Am J Cancer Res

IF：5.884



Article：RPL34-AS1–induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway

Periodicals：Cancer Science

IF：4.966



Article：Sp1-Mediated circRNA circHipk2 Regulates Myogenesis by Targeting Ribosomal Protein Rpl7

Periodicals：Genes

IF：3.757



Article：Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

Periodicals：Technology in Cancer Research & Treatment

IF：3.399



Article：A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells

Periodicals：Bioengineered

IF：3.268



【2020年】




Article：LncRNA CSMD1-1 promotes the progression of Hepatocellular Carcinoma by activating MYC signaling

Periodicals：Theranostics

IF：8.698



Article：Epigenetic silencing of KLF2 by long non-coding RNA SNHG1 inhibits periodontal ligament stem cell osteogenesis differentiation

Periodicals：Stem Cell Research & Therapy

IF：5.081



Article：Deficiency of pseudogene UPAT leads to hepatocellular carcinoma progression and forms a positive feedback loop with ZEB1

Periodicals：Cancer Science

IF：4.985



Article：Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer

Periodicals：iScience

IF：4.447



Article：LINC00689 promotes prostate cancer progression via regulating miR-496/CTNNB1 to activate Wnt pathway

Periodicals：Cancer Cell International

IF：3.991




Article：CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p

Periodicals：OncoTargets and Therapy

IF：3.259



【2019年】



Article：CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth

Periodicals：Journal of Experimental & Clinical Cancer Research

IF：7.038




Article：PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression

Periodicals：Cell Death & Disease

IF：6.28



Article：Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

Periodicals：Clinical Epigenetics

IF：5.156



Article：CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression

Periodicals：Frontiers in Oncology

IF：4.137



【2017年】



Article：LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1

Periodicals：Journal of Cellular and Molecular Medicine

IF：4.302